Custom Peptides
Cayman Chemical 2-Hydroxyadipic Acid, Purity: ≥95%, CAS: 18294-85-4, 10 mg
A dicarboxylic fatty acid; levels are decreased in tumor tissue from patients with esophageal squamous cell carcinoma; levels are increased in patients with 2-ketoadipic aciduria
Cayman Chemical Methylprotodioscin, Purity: ≥98%, CAS: 54522-52-0, 10 mg
A steroidal saponin with diverse biological activities; suppresses EGF- or PMA-induced MUC5AC mucin production in H292 cells at 1 µM; inhibits the proliferation of HeLa cervical cancer cells (IC50 = 18.31 µM); induces production of ROS, apoptosis, and cell cycle arrest at the G2/M phase in HeLa cells; decreases bone loss and prevents decreases in bone mineral content and bone mineral density in a mouse model of ovariectomy-induced osteoporosis at 50 mg/kg
Cayman Chemical Pentadecanoyl-L-carnitine (chloride), Purity: ≥98%, CAS: 173686-57-2, 10 mg
A CB receptor agonist (EC50s = 3.7 and 3.2 µM for CB1 and CB2 receptors, respectively, in a cAMP modulation assay); a 5-HT1A and 5-HT1B agonist (EC50s = 9.6 and 9.3 µM, respectively); a histamine H1 and H2 antagonist (EC50s = 10.9 and 6.1 µM, respectively); inhibits T cell proliferation in an SAg primary human cell system; reduces CCL2 levels in an Mphg primary human cell system
Cayman Chemical Isomeranzin, Purity: ≥98%, CAS: 1088-17-1, 10 mg
A coumarin with antioxidant and anti-inflammatory activities; inhibits superoxide anion generation in, and elastase release from, cytochalasin B- and fMLP-stimulated isolated human neutrophils (IC50s = 3.89 and 4.33 µM, respectively); inhibits LPS-induced NO release in RAW 264.7 macrophages at 30 µM; improves survival in a mouse model of LPS-induced septic shock and decreases disease severity in a mouse model of DSS-induced colitis at 30 mg/kg
Cayman Chemical Periplogenin, Purity: ≥98%, CAS: 514-39-6, 10 mg
A cardenolide and an active metabolite of periplocin with diverse biological activities; reduces the activity of porcine Na+/K+ ATPase at 0.3 or 0.6 µM; induces apoptosis in U937 and PC3 prostate cancer cells, as well as inhibits the proliferation of these cells (EC50s = 1.41 and 1.2 µM, respectively) at 0.1 or 0.2 µM; increases ROS production and induces necroptosis in HaCaT keratinocytes at 2 µg/ml; reduces ear thickness in a mouse model of TPA-induced psoriasis
Cayman Chemical Kaempferol 7-neohesperidoside, Purity: ≥95%, CAS: 17353-03-6, 10 mg
A flavonoid glycoside with antioxidant and anticancer activities; scavenges DPPH radicals in a cell-free assay (IC50 = 7.4 µM); cytotoxic to A549, HepG2, and HeLa cells (IC50s = 0.53, 0.2, and 0.051 µM, respectively)
Cayman Chemical Oseltamivir Acid methyl ester, Purity: ≥95%, CAS: 208720-71-2, 10 mg
A prodrug form of oseltamivir acid
Cayman Chemical FPL 55712 (sodium salt), Purity: ≥98%, CAS: 40786-08-1, 10 mg
An LT receptor antagonist; inhibits LTD4 binding to guinea pig lung homogenates (IC50 = 4 µM) and reduces LTD4-induced contraction of isolated guinea pig tracheal smooth muscle (pA2 = 1 µM); inhibits LTD4-, LTC4-, or LTE4-induced bronchoconstriction in guinea pigs (ID50s = 2, 6, and 1 mg/kg, respectively)
Cayman Chemical β-Cortolone, Purity: ≥95%, CAS: 667-66-3, 10 mg
A metabolite of cortisol; urinary levels are decreased in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma
Cayman Chemical JQKD82 (hydrochloride), Purity: ≥98%, CAS: 2863676-87-1, 10 mg
A prodrug form of KDM5-C49; increases the levels of H3K4me3 in MOLP-8 and MM.1S cells at 0.3 and 1 µM; reduces the proliferation of MOLP-8 and MM.1S cells in a concentration-dependent manner; decreases the viability of primary CD138+ cells from patients with multiple myeloma at 3 µM; induces cell cycle arrest at the G0/G1 phase, as well as induces apoptosis, in MOLP-8 and MM.1S cells at 1 µM; decreases tumor growth and increases survival in a MOLP-8 mouse xenograft model at 50 mg/kg twice per day
Cayman Chemical A8SGLP-1 (trifluoroacetate salt), Purity: ≥98%, CAS: 753024-08-7, 10 mg
A peptide agonist of GLP-1R and a derivative of GLP-1 (7-36) amide; induces cAMP accumulation in RIN T3 cells (EC50 = 15 nM); reduces blood levels of glucose in the OGTT, serum levels of Il-1β, Il-6, and Tnf-α, and fat mass in diabetic db/db mice in lyophilized L. lactis, p.o.
Cayman Chemical 1,2-Dierucoyl-sn-glycero-3-PE, Purity: ≥98%, CAS: 904304-57-0, 10 mg
A phospholipid; has been used in the generation of LNPs for the delivery of mRNA in vivo; has been used in the synthesis of various PEG-conjugates for incorporation into liposomes; LNPs containing 1,2-dierucoyl-sn-glycero-3-PE and encapsulating mRNA encoding hEPO increase serum hEPO levels in mice
Cayman Chemical MCC950 (sodium salt), Purity: ≥98%, CAS: 256373-96-3, 10 mg
An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg
Cayman Chemical Brevifolincarboxylic Acid, Purity: ≥95%, CAS: 18490-95-4, 10 mg
A phenol with anticancer and anti-inflammatory activities; inhibits the proliferation of PC-14 lung cancer cells (IC50 = 3.95 µg/ml); reduces LPS-induced increases in NO production in RAW 264.7 macrophages at 20 µM